MANCHESTER, England (AP) — Arsenal blew the chance to go top of the English Premier League after a shock 2-0 loss to Bournemouth on Saturday.

In one of the biggest upsets of the burgeoning season, 10-man Arsenal lost for the first time.

Mikel Arteta’s team finished runner-up in the last two years and could have leapfrogged leader Liverpool and defending champion Manchester City in second place with a win at Bournemouth.

But Arsenal’s chances were hit after William Saliba was sent off in the first half at Vitality Stadium. Bournemouth took full advantage with Ryan Christie scoring in the 70th minute and Justin Kluivert converting a penalty nine minutes later.

“It’s hard enough to play here 11 against 11, we made life very difficult for ourselves again," Arteta said. Arsenal's third red card of the season, he added, was “an accident waiting to happen.”

Third-placed Arsenal is a point behind Liverpool and level with City, having played a game more than its rivals, who are both in action on Sunday.

Meanwhile, Manchester United picked up only its third league win by beating Brentford 2-1.

Fourth-placed Aston Villa tightened up the top of the standings by moving to within a point of Liverpool and level with Arsenal after beating Fulham 3-1. Brighton was three points off the pace after winning at Newcastle 1-0.

Tottenham scored three times in eight minutes in a 4-1 win over West Ham.

Seeing red

Red cards are proving costly for Arsenal. This was the third time the London club has been reduced to 10 men and it has yet to win any of those games.

Declan Rice was sent off against Brighton in a 1-1 draw in August and Leandro Trossard saw red in the 2-2 draw with City last month.

“We can’t make silly mistakes," Rice said. “You need all your best players on the pitch at all times.”

Garnacho stunner

Alejandro Garnacho scored from a brilliant volley as United fought back to beat Brentford at Old Trafford.

The Argentina international fired home from a tight angle when connecting with Marcus Rashford’s cross just after halftime.

It sparked a comeback that saw Rasmus Hojlund hit the winner and ease the pressure on manager Erik ten Hag.

“In this team you see its togetherness and there is a fighting spirit,” Ten Hag said. “And today we add some determination to score goals and that is what we needed.”

United was reeling from its worst season start in the Premier League era heading into Saturday’s game and it looked like being another disappointing day for Ten Hag, who was angered when Ethan Pinnock opened the scoring for Brentford in contentious circumstances in first-half added time.

United defender Matthijs de Ligt was ordered off for medical attention on his bleeding head from a collision. It left the home team down a man as Brentford prepared to take a corner and Pinnock headed over the line in the fifth minute of added time.

United responded quickly after the break thanks to Garnacho’s goal in the 47th.

Hojlund flicked past Brentford goalkeeper Mark Flekken for the winner in the 62nd.

“We don’t score enough, we are not clinical enough. But today we scored two brilliant goals,” Ten Hag said. “It’s only one win, but it can help us.”

Villa rises

Villa was up to fourth after coming back from going a goal down at Craven Cottage when Raul Jimenez fired Fulham in front in the fifth minute.

Morgan Rogers quickly leveled four minutes later and Ollie Watkins made it 2-1 in the 59th. An Issa Diop own goal in the 69th completed the scoring.

Southampton collapses

Leading 2-0 after 28 minutes at St Mary’s Stadium, last-placed Southampton looked on course for its first league win.

Leicester had other ideas.

Second-half goals from Facundo Buonanotte, Jamie Vardy from the penalty spot, and Jordan Ayew secured an unlikely comeback that left Southampton rooted to the bottom of the table and moved Leicester six points clear of the relegation zone.

Also, Everton extended its unbeaten run to four games by beating winless Ipswich 2-0.

Brighton flying high

Brighton’s impressive start under coach Fabian Hurzeler continued with the win at Newcastle.

Hurzeler, born in Texas, has made his presence felt in England’s top flight following his appointment in the offseason.

Hurzeler is also working wonders with Danny Welbeck, who scored in the 35th at St James’ Park, his fifth goal of the season.

Spurs comeback

Tottenham trailed to Mohammed Kudus' 18th-minute goal at Tottenham Hotspur Stadium but powered back with a brilliant second-half performance.

Dejan Kulusevski leveled in the 36th and after the break the home team took control. Yves Bissouma struck in the 52nd and Alphonse Areola scored an own goal three minutes later.

Son Heung-min added a fourth on the hour mark.

West Ham was reduced to 10 men in the 86th when Kudus was sent off for pushing Micky van de Ven in an angry confrontation.

___

James Robson is at https://twitter.com/jamesalanrobson

___

AP soccer: https://apnews.com/hub/soccer

Manchester United's head coach Erik ten Hag, right, and Brentford's head coach Thomas Frank react during the English Premier League soccer match between Manchester United and Brentford at Old Trafford stadium in Manchester, England, Saturday, Oct. 19, 2024. (AP Photo/Dave Thompson)

Credit: AP

icon to expand image

Credit: AP

Bournemouth's Ryan Christie celebrates after scoring his side's opening goal during the English Premier League soccer match between Bournemouth and Arsenal at the Vitality Stadium in Bournemouth, England, Saturday, Oct. 19, 2024. (AP Photo/Kin Cheung)

Credit: AP

icon to expand image

Credit: AP

AFC Bournemouth players celebrate after Bournemouth's Justin Kluivert scored his side's second goal during the English Premier League soccer match between Bournemouth and Arsenal at the Vitality Stadium in Bournemouth, England, Saturday, Oct. 19, 2024. (AP Photo/Kin Cheung)

Credit: AP

icon to expand image

Credit: AP

Manchester United's Alejandro Garnacho reacts after missing a chance to score during the English Premier League soccer match between Manchester United and Brentford at Old Trafford stadium in Manchester, England, Saturday, Oct. 19, 2024. (AP Photo/Dave Thompson)

Credit: AP

icon to expand image

Credit: AP

Fans watch from the stands during the English Premier League soccer match between Manchester United and Brentford at Old Trafford stadium in Manchester, England, Saturday, Oct. 19, 2024. (AP Photo/Dave Thompson)

Credit: AP

icon to expand image

Credit: AP

Manchester United's head coach Erik ten Hag applauds to supporters before the English Premier League soccer match between Manchester United and Brentford at Old Trafford stadium in Manchester, England, Saturday, Oct. 19, 2024. (AP Photo/Dave Thompson)

Credit: AP

icon to expand image

Credit: AP

Manchester United's Matthijs de Ligt reacts during the English Premier League soccer match between Manchester United and Brentford at Old Trafford stadium in Manchester, England, Saturday, Oct. 19, 2024. (AP Photo/Dave Thompson)

Credit: AP

icon to expand image

Credit: AP

Manchester United's head coach Erik ten Hag reacts during the English Premier League soccer match between Manchester United and Brentford at Old Trafford stadium in Manchester, England, Saturday, Oct. 19, 2024. (AP Photo/Dave Thompson)

Credit: AP

icon to expand image

Credit: AP

Tottenham Hotspur's Dejan Kulusevski, center, celebrates scoring with teammates during the English Premier League soccer match between Tottenham Hotspur and West Ham United at the Tottenham Hotspur Stadium, London, Saturday Oct. 19, 2024. (Zac Goodwin/PA via AP)

Credit: AP

icon to expand image

Credit: AP

Tottenham Hotspur's Son Heung-Min, left, celebrates scoring with fans during the English Premier League soccer match between Tottenham Hotspur and West Ham United at the Tottenham Hotspur Stadium, London, Saturday Oct. 19, 2024. (Zac Goodwin/PA via AP)

Credit: AP

icon to expand image

Credit: AP

Leicester City's Jamie Vardy celebrates scoring his side's second goal of the game , during the English Premier League soccer match between Southampton and Leicester City, at St Mary's Stadium, in Southampton, England, Saturday, Oct. 19, 2024. (Adam Davy/PA via AP)

Credit: AP

icon to expand image

Credit: AP

Aston Villa's Amadou Onana celebrates their side's third goal of the game, via an own-goal scored by Fulham's Issa Diop during the English Premier League soccer match between Fulham and Aston Villa at Craven Cottage in London, Saturday Oct. 19, 2024. (John Walton/PA via AP)

Credit: AP

icon to expand image

Credit: AP

Aston Villa goalkeeper Emiliano Martinez celebrates in front of the fans after the final whistle in the English Premier League soccer match between Fulham and Aston Villa at Craven Cottage, London, Saturday Oct. 19, 2024. (John Walton/PA via AP)

Credit: AP

icon to expand image

Credit: AP

Ipswich Town's Sammie Szmodics is challenged by Everton's Ashley Young, left, and Jack Harrison, right, during the English Premier League soccer match between Ipswich Town and Everton at Portman Road, Ipswich, Saturday Oct. 19, 2024. (Bradley Collyer/PA via AP)

Credit: AP

icon to expand image

Credit: AP